|
October 23, 2026 — FxNutrition Intelligence
Evidence-driven intelligence for functional nutrition practitioners
A Nutrishify publication • Week of October 23, 2026
|
|
Two grams a day of plant sterols did not lower LDL-cholesterol in a small trial of adults with obesity. GLP-1 receptor agonists also showed no clear gain in global cognition across five trials. Plus: protein added to resistance training raised squat strength by 7.40 kg in young adults.
And a heartfelt thank-you to the readers who shared such kind words about this newsletter. They mean a great deal.
|
|
Evidence Spotlight
|
Plant Sterols in Obesity
A small crossover trial of 23 adults with obesity (mean BMI 36.4) found that 2 g/day of plant sterols for 8 weeks did not change LDL-cholesterol versus placebo. The change from baseline was +0.1 mg/dL after plant sterols (95% CI −7.1 to 7.3) and +3.9 mg/dL after placebo (95% CI −7.6 to 15.4). The between-treatment p value was 0.632.
No other lipid, hs-CRP, glucose, body-composition, sarcopenia, or lifestyle difference between the two phases stayed significant after correction for multiple testing. The trial was powered for LDL-cholesterol only.
Takeaway: In this group with obesity, the LDL drop often expected from plant sterols did not appear. The trial was small and built to answer the cholesterol question, not body composition.
Read study → The American Journal of Clinical Nutrition, October 16, 2026
|
Protein and Lifting Strength
Across 23 randomized trials and 611 healthy young adults, adding protein to resistance training increased strength beyond training alone. Bench press was 2.63 kg higher (95% CI 0.77 to 4.49) and squat strength was 7.40 kg higher (95% CI 2.15 to 12.66).
The squat difference showed up mainly when the program lasted 12 weeks or less, or when protein was taken around the workout and before sleep. The authors say that extra benefit depends on duration, timing, training background, and how much protein people already eat.
Takeaway: Protein on top of lifting added measurable strength in young adults, with the clearest squat signal in shorter programs and with workout-plus-bedtime timing. Dose and protein source were not reported in one standard way.
|
GLP-1 Drugs and Cognition
Five randomized trials, 13,711 adults with type 2 diabetes or mild cognitive impairment, did not show a benefit of GLP-1 receptor agonists on global cognition. Mean age was 64.5 years and mean follow-up was 28.4 months. The pooled result was flat: Hedges’ g = 0.014 (95% CI −0.061 to 0.088; p = 0.515).
Four of the five trials contributed compatible cognitive data. Attention was also flat. Delayed memory, executive function, and verbal function each came from a single trial, so they were not pooled. This is a drug analysis, not a diet or supplement trial.
Takeaway: These trials do not show a consistent cognitive benefit from GLP-1 receptor agonists in adults at risk of Alzheimer’s disease. A null on cognition is separate from the metabolic reasons people take these drugs.
|
|
By The Numbers
⬆︎7.40 kg
Protein plus lifting added 7.40 kg of squat strength versus training alone.
Bench press added 2.63 kg in the same 23 trials of healthy young adults.
|
|
|
Clinical Pearl
Plant sterols did not lower LDL in obesity
In 23 adults with obesity, 2 g/day for 8 weeks did not change LDL-cholesterol versus placebo. Other lipids, hs-CRP, glucose, and body composition also showed no difference that held up after correction for multiple testing. The trial was powered for LDL-cholesterol only.
|
|
|
|
Recent Podcasts
|
What New Research Reveals About Reversing Cognitive Decline
New Frontiers in Functional Medicine • October 22, 2026
Useful if clients ask whether cognitive decline has to run in one direction. Dr. Kara Fitzgerald discusses research that questions whether cognitive decline is only a one-way process, and what may be possible when the drivers of impairment are addressed. The episode page frames that question around Bredesen and Toups. Listen →
|
Essentials: Developing a Rational Approach to Supplementation for Health & Performance
Huberman Lab • October 22, 2026
Useful if you are tightening how you choose supplements with clients. Andrew Huberman walks through a supplementation protocol built around needs, diet, and budget, including foundational supplements and single-ingredient options for sleep, hormone support, and focus. Listen →
|
4 food groups to lower inflammation, support your immune system and help you age well | Dr Jeffrey Bland
The Doctor’s Kitchen • October 21, 2026
A food-first listen on inflammation, immune function, and aging. Dr. Rupy Aujla talks with Dr. Jeffrey Bland about food compounds as signals for gut microbes, immune response, and gene expression, and about four food groups tied to inflammation and aging. Listen →
|
20,000 Women Surveyed: What the Data Reveals About Menopause Symptoms
The DUTCH Podcast • October 20, 2026
Useful if menopause symptom patterns are showing up in your caseload. Dr. Jaclyn Smeaton talks with nutritionist Andrea Donsky about a large survey of perimenopause and menopause symptoms, gut health and hormone balance, and baseline hormone and metabolic testing. Listen →
|
EP241: Root Causes: Exploring the Hidden Links Between Your Mouth and Your Health – Corbin Popp, DMD
BetterHealthGuy Podcast • October 19, 2026
Useful if oral findings keep coming up alongside systemic symptoms. Corbin Popp, DMD, covers the oral microbiome, remineralization, xylitol, mercury removal, and how dental findings connect to systemic care. Listen →
|
|
Mark Your Calendar
|
October 27
Atrial Fibrillation: Emerging Risk Factors and Laboratory Insights
Webinar | Genova Diagnostics | 7–8 PM ET | 4–5 PM PT | Register →
|
October 27
Infrared Insights: Unlocking the Science of Light Therapy for Healthspan and Lifespan
Webinar | Personalized Lifestyle Medicine Institute | 5–7 PM PT | Register →
|
October 28
Mitochondria, Muscle and Menopause: The Clinical Case for Urolithin A in Perimenopause
Webinar | Timeline | 12 PM ET | Register →
|
November 4
Built to Help Others. Here’s Why Your Own Money Feels Different
Workshop | American Nutrition Association | 5 PM EST | CEUs available | Register →
|
November 12
The Exposure Equation: Rethinking Toxin Prevention in Clinical Practice
Webinar | CellCore Biosciences | 6 PM MST | 8 PM EST | Register →
|
|
Tech Tip
|
See your link preview before you post it
When a link is shared on LinkedIn, the title, description and image in the preview come from hidden tags on the web page, not from the post itself. LinkedIn also saves that preview, so a page updated after its first share can keep showing an old title or the wrong photo. LinkedIn’s free Post Inspector (sign in to LinkedIn first) handles both: paste in any web address to see exactly what the preview will look like, and the tool grabs a fresh copy at the same time. For Facebook, Meta’s Sharing Debugger does the same (also sign-in required), with a Scrape Again button to refresh the saved copy.
Do this: before sharing a new blog post, event page or practice website, run it through both tools first. If the image is missing, the page usually needs a featured image set.
|
|
© 2026 Nutrishify · Questions or feedback? Email hello@nutrishify.com
|
|
