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October 2, 2026 — FxNutrition Intelligence
Evidence-driven intelligence for functional nutrition practitioners
A Nutrishify publication • Week of October 2, 2026
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Eating about 95% of energy from ultra-processed foods for two weeks didn’t blunt satiety hormones in a small crossover trial, which complicates a popular explanation for overeating. Plus: a fiber blend added to a low FODMAP diet, and a human trial of protocatechuic acid and blood vessel function.
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Evidence Spotlight
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Fiber Blend on Low FODMAP
A small but notable randomized, double-blind pilot (n=26) in adults with irritable bowel syndrome (IBS) tested a 3-week fiber blend (ur gut®) added to a low FODMAP diet, which restricts certain fermentable carbohydrates. Compared with placebo, the fiber group ate less energy and protein than the placebo group and more resistant starch than at baseline, and showed a shift in gut bacteria, including a 5.5-fold rise in Ruminococcus E.
Gut symptoms and sleep stayed stable in both groups, and GI-specific anxiety improved in the fiber group (P=0.01). Stool and blood biomarkers did not change, the abstract does not detail the blend’s exact composition, and only 3 of the 26 participants were male.
Takeaway: Adds to the question of how to support gut bacteria when clients restrict fermentable carbohydrates. A 3-week pilot of this size is an early signal to follow, not settled evidence.
Read study → European Journal of Nutrition, September 24, 2026
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Ultra-Processed Food & Satiety
A small but notable randomized crossover trial (n=32) challenges the idea that ultra-processed food (UPF) blunts satiety signaling. Adults with habitually low UPF intake ate two 14-day diets providing about 95% of energy from UPFs, separated by a 14-day washout. Their satiety hormone responses to a fixed-calorie meal (glucagon-like peptide-1, ghrelin, pancreatic polypeptide, and peptide YY) did not differ from baseline.
Total hunger and fullness ratings did shift slightly, with higher hunger and lower fullness after the UPF diets, but no single timepoint differed significantly, and daily fasting appetite ratings stayed stable. Participants were young (average age 27) and normal weight on average, and exposure lasted only 14 days.
Takeaway: Suggests that, at least over two weeks in young healthy adults, impaired satiety hormone signaling may not be the mechanism behind the high energy intake linked to UPFs.
Read study → European Journal of Nutrition, September 24, 2026
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Protocatechuic Acid & Vessel Function
A 12-week randomized, double-blind, placebo-controlled trial (n=150) in adults aged 35 to 65 with high cholesterol found that 20 mg a day of protocatechuic acid (PCA) improved blood vessel function, measured as brachial artery flow-mediated dilation (FMD), by 1.77% more than placebo. Earlier evidence for PCA’s vessel effects came from mice.
PCA also raised serum cyclic guanosine monophosphate (cGMP), increased HDL3 and lowered HDL2 (high-density lipoprotein subtypes), and raised the endothelial nitric oxide synthase (eNOS) activity of HDL, while total HDL did not change significantly. The authors say the findings need confirmation in larger, longer trials.
Takeaway: Relevant when clients ask about supplement research for cholesterol and vascular health. FMD is a surrogate marker, so the trial does not show whether PCA changes heart disease outcomes.
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By The Numbers
95% of energy
from ultra-processed foods for 14 days did not change satiety hormone responses in a crossover trial of 32 adults.
Adults with habitually low ultra-processed food intake ate two 14-day diets built almost entirely from UPFs. Hormone responses to a fixed-calorie meal matched baseline, though total hunger ratings were slightly higher and fullness slightly lower.
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Clinical Pearl
Fiber blend shifted gut bacteria on a low FODMAP diet
In a 3-week pilot of 26 adults with IBS following a low FODMAP diet, those given a fiber blend (ur gut®) ate more resistant starch and showed shifts in gut bacteria, with gut symptoms staying stable. The authors describe it as a way to support gut health without compromising symptom control.
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Recent Podcasts
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Menopause Botanicals: Identity, Standardization & Patience
The Root Cause Medicine Podcast • October 1, 2026
Useful when clients ask whether a menopause botanical product matches what was studied. Dr. Eric Viegas reviews black cohosh, Vitex (chasteberry), rhapontic rhubarb, maca, and soy isoflavones through three lenses: confirming the plant identity, whether the extract is standardized, and allowing enough time before judging a product. Listen →
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ADHD in Women: How Hormones, Gut Health & Inflammation Are Linked
The DUTCH Podcast • September 29, 2026
Relevant for practitioners seeing midlife clients with new attention and focus complaints. Dr. Jaclyn Smeaton hosts Dr. Jolene Brighten on how estrogen shapes brain energy, immune function, and gut microbial diversity, why ADHD in women is often missed until adulthood, and how falling estrogen in perimenopause can bring on or intensify ADHD-like symptoms. Listen →
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The Best Brain Foods, Protein Truth, Alzheimer’s Myth & AI Overlords
The Art of Being Well • September 28, 2026
A wide-ranging listen on brain-supportive eating and the protein, seed oil, and saturated fat debates. Dr. Will Cole talks with Max Lugavere, author of Genius Foods, about his mother’s Lewy body dementia, why the amyloid plaque model of Alzheimer’s is being challenged, and what the science says about protein, seed oils, and saturated fat. Listen →
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Building Muscle in Menopause: Protein, Creatine and Strength Training
unPAUSED • September 25, 2026
Useful if you’re refining how you discuss protein and muscle with midlife clients. Dr. Mary Claire Haver continues her conversation with Dr. Gabrielle Lyon on anabolic resistance, why Dr. Lyon favors 30 to 50 grams of protein at the first meal, where creatine and essential amino acids fit, and her concerns about glucagon-like peptide-1 (GLP-1) medications and muscle loss. Listen →
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Live Younger Longer
On Nutrition (Mayo Clinic Press) • April 7, 2026
A dietitian-hosted conversation on eating for longevity with a Mayo Clinic cardiologist. Registered dietitian Tara Schmidt talks with cardiologist Dr. Stephen Kopecky about the eleven foods linked to longevity and the healthy aging tips from his book, Live Younger, Longer. Listen →
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Mark Your Calendar
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October 7
Elemental Archive: Hair as an Indicator of Toxic Exposure and Nutritional Element Status
Webinar | Doctor’s Data | 12 PM PT | Register →
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October 7
Gut–Mitochondria Crosstalk: A Systems Biology Approach to Cellular Signaling and Systemic Resilience
Webinar | Researched Nutritionals | 3–4:15 PM PT | Register →
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October 8
Building Resilience for Breast Cancer
Free 3-Part Course | Genova Diagnostics | Register →
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October 16
XYMOGEN XPERIENCE 2026
In-Person Conference, Orlando, FL (October 16–18) | XYMOGEN | Register →
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October 19
Supplements for Bone Health during Perimenopause: Supplement Deep Dive
Practitioner Training | Camille Freeman / Bloom & Grow Academy | 5–6:30 PM ET | CEUs available | Register →
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Org/Industry Updates
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ARG Updates Tocotrienol Formulas
Allergy Research Group updated Tocotrienols 200 mg (formerly Tocomin SupraBio®) to use TocoGaia ULTRA®, a full-spectrum palm tocotrienol source, and notes a light orange color change. Delta-Fraction Tocotrienols 125 mg now uses TheraPrimE® Annatto Tocotrienols 90 with the same 90% delta and 10% gamma profile, with rice bran oil added. Red Yeast Rice w/ CoQ10, Niacin, and Deluxe Scavengers received other-ingredient updates for stability, with active ingredients unchanged. View updated product →
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Tech Tip
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The big AI assistants can now read your clients’ health data
Since early 2026, ChatGPT, Claude, Microsoft Copilot, and Perplexity have each added a way to connect Apple Health and wearable data, plus hospital records or lab results in the U.S. All four say connected health data is not used to train their models. Access varies: Claude and Perplexity require paid plans, ChatGPT includes free ones, and Copilot is rolling out in phases. The practical result: clients may arrive with sleep trends or lab results already summarized by an AI that has no clinical context.
Do this: add one intake question: “Have you connected your health data to an AI tool?” Treat what it told them as a question to explore, not a finding.
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