May 22, 2026 — FxNutrition Intelligence
Evidence-driven intelligence for functional nutrition practitioners
A Nutrishify publication • Week of May 22, 2026
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A prebiotic intervention shifted SCFA-producing gut bacteria in children with Type 1 diabetes—without moving HbA1c at all. That disconnect between microbiome response and glycemic control is worth understanding. Also this week: 81,770 semaglutide adverse event reports reveal which side effects dominate in real-world use. Plus, we've reformatted the Evidence section to make it more useful—let us know what you think.
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Gut Shift, Flat Blood Sugar
Prebiotic fiber shifted kids' gut bacteria in 12 weeks but didn't budge their blood sugar. The microbiome responded (more bacteria that make short-chain fatty acids); HbA1c stayed flat.
Pilot RCT with 61 kids (ages 8–18) with Type 1 diabetes: 8g/day inulin versus placebo for 12 weeks. Gut changes and blood sugar control don't always move on the same timeline.
Takeaway: Microbiome shifts don't guarantee short-term blood sugar improvements in pediatric T1DM.
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EEN vs Steroids, One Year
Exclusive enteral nutrition (EEN) matched steroids for treating kids' small-bowel Crohn's disease at one year — same remission rates, growth, and time to surgery. EEN is a legitimate first-line option, not a fallback.
Multicenter study of 208 kids (ages 2–18) with new small-bowel Crohn's: EEN versus corticosteroids as first treatment. One-year outcomes (steroid-free remission, growth, surgery timing) were statistically similar.
Takeaway: EEN performs as well as steroids for pediatric small-bowel Crohn's induction — useful data point when families weigh options.
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Semaglutide Side Effect Reports
Gut complaints dominate semaglutide's real-world side effect reports (28% of 81,770 global reports), matching what clinicians already see. Metabolism and nutrition issues made up 7% — worth tracking as GLP-1 use grows.
Analysis of global adverse event reports through October 2025. GI issues were most common, followed by injection-site reactions (12%) and injury or complications (11%). Reporting rose as prescribing expanded.
Takeaway: GI side effects lead, but the metabolism/nutrition category (7%) warrants attention in safety conversations.
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By The Numbers
81,770
Adverse event reports linked to semaglutide in the WHO global pharmacovigilance database—and 28% of them were gastrointestinal.
As GLP-1 prescribing has expanded rapidly since 2018, so has the global adverse event signal. This WHO-VigiAccess analysis found gastrointestinal disorders were the dominant complaint category—consistent with the drug's known mechanism. Worth noting for nutrition practitioners: metabolism and nutrition disorders accounted for 7% of reports, a category that points toward monitoring nutritional status in clients on these medications, not just managing GI tolerability.
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Clinical Pearl
Prebiotics can shift gut bacteria even when blood sugar doesn't change
This 12-week pilot found gut bacteria shifted without HbA1c movement in kids with Type 1 diabetes — a reminder that gut changes and glucose markers don't always track together on a short clock.
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New GLP1 Risks & Exercise as a Mental Health Prescription
The Root Cause Medicine Podcast • May 21, 2026
Useful when discussing GLP-1 therapies and bone-related lab context. Dr. Carrie Jones and Dr. Kate Kresge cover an observational study linking GLP-1 use to higher rates of osteoporosis, osteomalacia, and gout during rapid weight loss, plus a British Journal of Sports Medicine umbrella review on exercise for depression and anxiety, including markers such as alkaline phosphatase, vitamin D, calcium, phosphate, and PTH. Listen →
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7 Health benefits of fibremaxxing and how to build a high fibre diet
The Doctor's Kitchen • May 20, 2026
A food-first orientation on fiber across systems. Dr. Rupy Aujla and Dr. Karan Rajan walk through fiber's benefits across skin, brain, hormones, and inflammation, including whether 30g/day is enough, how to manage bloating when increasing intake, and how to think about fiber diversity. Listen →
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Cracking the Hashimoto's Code: Toxins, Stress & Smarter Testing
The DUTCH Podcast • May 19, 2026
A good listen when thyroid panels feel incomplete. Dr. Jaclyn Smeaton speaks with Inna Topiler about why standard thyroid testing can miss the full picture in Hashimoto's, including stress, infections, toxins, and food sensitivities, and how cortisol patterns on DUTCH testing show up in these cases. Listen →
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Decoding Muscle and Bone Health with Dr. Jocelyn Wittstein
Decoding Women's Health with Dr. Elizabeth Poynor • May 19, 2026
Worth your time if clients are asking about bone and muscle around menopause. Dr. Elizabeth Poynor and Dr. Jocelyn Wittstein discuss estrogen loss, muscle and bone density, practical resilience habits, and how DEXA access is showing up beyond traditional clinical channels. Listen →
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#392 – Genetic testing: when it's valuable, how to choose the right test, and what to do with the results
The Peter Attia Drive • May 18, 2026
A structured frame for genetic testing questions. Peter Attia's solo episode #392 walks through cardiovascular, metabolic, oncological, and neurodegenerative domains; pharmacogenetics; lab selection; genetic risk versus phenotypic measurement; and a critique of functional-medicine genetic panels that drive supplement protocols without strong supporting evidence. Listen →
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May 21
NIH ORWH virtual roundtable — pelvic floor dysfunction, research gaps, and multidisciplinary care
Virtual roundtable • NIH Office of Research on Women's Health (ORWH) • 3:00 PM – 4:30 PM ET — Register →
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May 21
How to Train Your Immune System to Fight Cancer: The Science of Trained Immunity (live with Dr. Michael Karlfeldt)
Live training • Better Way Health • 7:00 PM ET — Register →
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Tech Tip: Stop Paying for Loom
Google Vids is free (included with Google Workspace or free personal accounts) and does everything Loom does — plus more.
What you can do:
- Screen record with camera, audio only, or screen only
- Edit by deleting words from the transcript (no timeline needed)
- Auto-generate stylized captions and AI voiceovers
- Use teleprompter that scrolls as you speak
- Publish directly to YouTube
- Export as MP4
Access it:
- Chrome extension: "Google Vids Screen Recorder" (record from anywhere)
- Or in your Google Workspace app picker (waffle icon)
Don't have Google Workspace? Try Cap — also free, no limits.
Bottom line: No reason to pay for Loom anymore.
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